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Herbal Extract · Metabolic Health

Berberine Extract
Berberis aristata

Berberis aristata Roxb. ex DC. · Family: Berberidaceae · Root Extract · Berberine HCl 97%

The most studied natural ingredient for metabolic health — standardised to 97% Berberine Hydrochloride by HPLC from Berberis aristata (Indian Barberry / Daruharidra) roots. Trusted by supplement, nutraceutical, and pharma formulators worldwide. GMP and ISO certified supply from India.

97% Berberine HCl HPLC Tested GMP Certified Non-GMO Halal & Kosher Non-Irradiated
Berberine extract powder (Berberis aristata) standardised to 97% Berberine HCl — bright yellow fine powder, SV Botanica India

Actual Product

Berberis aristata · 97% Berberine HCl · Actual Batch
97%
Berberine HCl (HPLC)
36 Mo
Shelf Life
GMP · ISO
Certified Facilities
100% #40
Mesh Pass
25 kg MOQ
Min. Order Quantity
10–15 Days
Lead Time

What is Berberine Extract?

A bright-yellow isoquinoline alkaloid — the metabolic-health cornerstone

Berberine is a quaternary isoquinoline alkaloid found in the roots, stems, and bark of several plants. SV Botanica produces it from Berberis aristata — known as Indian Barberry, Tree Turmeric, or Daruharidra in Ayurveda — whose roots carry one of the richest natural concentrations of berberine. The result is a vivid yellow, free-flowing powder standardised to 97% Berberine Hydrochloride by HPLC.

Berberine's signature mechanism is activation of AMP-activated protein kinase (AMPK), the body's master metabolic switch. Through this and related pathways it influences glucose uptake, lipid metabolism, and the gut microbiome — which is why it has become one of the most clinically researched natural ingredients in the blood-sugar, cholesterol, and metabolic-syndrome categories.

Our berberine is sourced from cultivated, non-irradiated raw material and verified GMO-free, with botanical identity and assay confirmed by HPLC against a reference profile. It is purified to a consistent yellow to yellowish-brown powder that passes 100% through a #40 mesh, ideal for capsules, tablets, and standardised nutraceutical blends.

We supply supplement brands, contract manufacturers, and Ayurvedic and pharma formulators across Europe, the USA, the Middle East, and Southeast Asia. New buyers can review our full herbal extract range or request a Certificate of Analysis and specification sheet before ordering.

Active Constituents

The protoberberine alkaloid profile of Berberis aristata

Berberine (Marker)

The primary isoquinoline alkaloid, quantified by HPLC as Berberine HCl at ≥97%. Drives AMPK activation and the extract's metabolic activity.

Palmatine

A closely related protoberberine alkaloid contributing antimicrobial and metabolic activity; a typical companion marker in Berberis extracts.

Jatrorrhizine

Protoberberine alkaloid with documented lipid-modulating and antioxidant effects in preclinical research.

Columbamine

Minor protoberberine alkaloid present in the native root, part of the characteristic HPLC fingerprint.

Berbamine

A bisbenzylisoquinoline alkaloid of Berberis aristata studied for cardiovascular and immunomodulatory activity.

Oxyacanthine

Bisbenzylisoquinoline alkaloid native to barberry root, complementing the protoberberine fraction.

Health Benefits & Research Backing

Evidence from clinical trials, meta-analyses, and mechanistic research

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Blood Glucose Support

Berberine activates AMPK and improves insulin sensitivity. Randomised trials report reductions in fasting glucose and HbA1c comparable in magnitude to metformin in type-2 diabetes populations — the basis for its leading position in blood-sugar supplements.

Ref: Yin J et al., 2008; Metabolism

Cholesterol & Lipids

Berberine up-regulates the LDL receptor through an ERK-dependent pathway distinct from statins, lowering LDL cholesterol and triglycerides. Meta-analyses confirm consistent improvements in lipid panels.

Ref: Kong W et al., 2004; Nature Medicine

Metabolic Syndrome & Weight

By targeting AMPK and adipocyte metabolism, berberine improves multiple components of metabolic syndrome — waist circumference, blood pressure, and insulin resistance — in clinical studies.

Ref: Hu Y et al., 2012; Phytomedicine
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Gut Microbiome & GI

Berberine has a long traditional use for digestive complaints and exerts antimicrobial and prebiotic-like effects, favourably reshaping gut microbiota composition — increasingly linked to its metabolic benefits.

Ref: Zhang X et al., 2012; PLoS ONE

PCOS & Hormonal Metabolic

In polycystic ovary syndrome, berberine has been shown to improve insulin resistance and lipid metabolism, making it a popular ingredient in women's metabolic and hormonal-support formulas.

Ref: Wei W et al., 2012; Eur J Endocrinol
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Antioxidant & Anti-inflammatory

Berberine modulates inflammatory signalling (NF-κB) and reduces oxidative stress markers, supporting its broader role in cardiometabolic and healthy-ageing formulations.

Ref: Li Z et al., 2014; Mediators Inflamm

Berberine is supplied as a dietary/nutraceutical ingredient. SV Botanica makes no therapeutic claims; finished-product claims and dosing are the brand owner's responsibility per destination-market regulations.

Available Grades & Standardisations

Select the right purity and form for your formulation requirement

Grade Berberine Content Assay Best For Certifications
Berberine HCl 97% Standard ≥97% Berberine HCl (anhydrous) HPLC Capsules, tablets, mainstream metabolic supplements GMP, ISO, Halal, Kosher
Berberine HCl 98% Premium ≥98% Berberine HCl (anhydrous) HPLC Pharmaceutical-grade and clinical-dose formulations GMP, ISO, Halal, Kosher
Berberine HCl 90% Entry ≥90% Berberine HCl HPLC Cost-sensitive blends and combination products GMP, ISO, FSSAI
Berberis aristata Root Extract Whole-herb 4:1 / 10:1 native or 5–10% berberine HPLC / UV Traditional Ayurvedic (Daruharidra) formulations GMP, ISO, FSSAI
Dihydroberberine Enhanced Reduced form, higher bioavailability HPLC Absorption-optimised, lower-dose products (on request) GMP, ISO

Current product specification on file: Berberine HCl 97% — Doc. SVB-PS-BA97-01 (Berberis aristata, roots; Berberine HCl ≥97.0% by HPLC). Berberine from Berberis aristata and Coptis chinensis source plants available; specify preferred botanical origin and grade at time of inquiry. Custom mesh sizes available for orders ≥100 kg.

Technical Specifications

Full analytical profile — Berberine HCl 97% grade (per Product Specification SVB-PS-BA97-01)

ParameterSpecificationTypical Result
Botanical SourceBerberis aristata Roxb. ex DC.Conforms
Plant FamilyBerberidaceae
Part UsedRoots
Identification (HPLC)HPLC profile complies with reference, all major peaksComplies
Marker CompoundBerberine Hydrochloride
Assay MethodHPLC (anhydrous basis)
Berberine HCl ContentNLT 97.0% w/w97.6%
ColourYellow to yellowish-brownConforms
Odour & TasteCharacteristicConforms
TextureFree-flowing powder without lumpsConforms
Particle Size100% through #40 mesh (USP <786>)100%
Water ContentNMT 12.0% w/w (USP <921>)8.4%
Residue on IgnitionNMT 0.1% w/w (USP <281>)0.06%
Heavy Metals (ICP-OES/MS)Pb ≤1.0 · As ≤1.0 · Cd ≤1.0 · Hg ≤0.1 ppmComplies
Total Aerobic Microbial CountNMT 3,000 CFU/gComplies
Total Yeast & MouldNMT 100 CFU/gComplies
ColiformsNegative / 10 gAbsent
E. coli / Salmonella / S. aureus / P. aeruginosaAbsentAbsent
Cultivation / SanitisingCultivated · Non-irradiatedConforms
GMO StatusGMO FreeConforms
Shelf Life36 months from manufacture (sealed, <30°C, dry, dark)
Packaging25 kg HDPE drum with inner PE liner; multi-wall kraft bag option

Specification per SV Botanica Product Specification SVB-PS-BA97-01 (Rev. 01). Typical results shown are representative of recent batches; a current batch-specific Certificate of Analysis, MSDS, and allergen/Non-GMO declarations are issued with every shipment. Specifications for 90%, 98%, and whole-root grades available on request.

Applications by Industry

Where Berberine Extract delivers measurable formulation value

Blood Sugar & Metabolic

  • Glucose-support capsules
  • Insulin-sensitivity blends
  • AMPK activator stacks
  • Metabolic syndrome formulas
  • GlucoseGuard-style products

Cardiovascular & Lipids

  • Cholesterol-management supplements
  • Heart-health combination products
  • Triglyceride-support blends
  • Red yeast rice combinations

Weight & Body Composition

  • Weight-management formulas
  • Appetite & metabolism stacks
  • Sports-nutrition recomposition
  • Keto & low-carb support

Gut & Digestive Health

  • Gut microbiome support
  • Digestive & GI wellness blends
  • Candida & balance formulas
  • Traditional Daruharidra tonics

Women's Metabolic Health

  • PCOS support supplements
  • Hormonal-metabolic blends
  • Insulin-resistance formulas
  • Inositol + berberine combos

Pharma & Nutraceutical

  • Standardised phytopharmaceuticals
  • Ayurvedic proprietary medicines
  • Clinical-dose tablets
  • Liposomal & phytosome delivery

Quality Assurance & Sourcing

From root to standardised alkaloid — traceable, tested, certified

Raw Material Sourcing: Berberis aristata roots are obtained from cultivated, authenticated material under Good Agricultural and Collection Practices (GACP). Botanical identity is confirmed by macroscopic, microscopic, and HPLC fingerprinting against a reference standard, ensuring the correct species and a consistent native alkaloid profile.

Manufacturing: Berberine is isolated and purified in GMP-certified, ISO-audited facilities using validated, controlled processes, then dried to a free-flowing powder. Each batch is released only after a full QC battery — HPLC assay for Berberine HCl, water content, residue on ignition, mesh-size verification, heavy-metals ICP-OES/MS, and a complete microbiological panel.

Documentation: Every shipment carries a batch-specific Certificate of Analysis (CoA), MSDS, Allergen Declaration, BSE/TSE-free statement, Non-GMO affidavit, and Country of Origin Certificate. Halal and Kosher certificates and a Phytosanitary Certificate for export are available on request. Buyers can request our specification sheet and CoA before placing an order.

Certifications

Full compliance for global B2B supply

GMP Certified Facility (WHO-GMP)
ISO 22000 Food Safety Management
HPLC Assay Verified (≥97%)
Halal Certified (on request)
Kosher Certified (on request)
FSSAI Licensed Manufacturer
APEDA Registered Exporter
Non-GMO Compliant
Non-Irradiated
Heavy-Metal & Microbiology Tested

Regulatory & Compliance Notes

Key information for global product registration and labelling

European Union

Berberine is used in food supplements across several EU member states, declared as Berberis aristata root extract. Note that some markets (e.g. Italy) apply maximum-daily-intake limits for berberine — always verify the rules of the destination market. Labelling must comply with Regulation (EU) 1169/2011.

United States

Berberine is marketed as a dietary ingredient under DSHEA (21 CFR Part 111), with no pre-market approval required for dietary supplements. Importer facility registration with the FDA is required. Structure-function claims are permissible with 30-day FDA notification and substantiation.

India & Other Markets

Berberis aristata (Daruharidra) is a classical Ayurvedic ingredient recognised under the Drugs and Cosmetics Act, and FSSAI-compliant for nutraceutical use under the FSS (Health Supplements, Nutraceuticals…) Regulations 2022. Widely accepted in the Middle East (Halal grades) and Southeast Asia, subject to local limits.

Berberine Resources & Guides

Deep-dive articles for formulators, buyers, and brand owners

Related Products

Frequently co-formulated with Berberine Extract in metabolic-health products

Frequently Asked Questions

Technical and commercial questions answered by our ingredients team

Source Berberine Extract from India's Trusted Exporter

GMP-certified, HPLC-tested, fully documented supply. 97% and 98% Berberine HCl grades available. Minimum order 25 kg. Samples available for qualified buyers.

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